Revisión sobre las características biológicas y estructurales de fucoidan y la posibilidad de extraerlo a partir de Sargassum sinicola

Authors

  • Ailin Robles López Cuéllar Universidad de Sonora
  • Gabriela Ramos Clamont Montfort Centro de Investigación en Alimentación y Desarrollo A.C.

DOI:

https://doi.org/10.29105/idcyta.v8i1.41

Keywords:

brown algae, fucoidan, bioactivity, extraction, material balance

Abstract

In recent years, interest has increased in the isolation of marine bioactives with great potential for the development of nutraceutical products and functional foods. In this sense, brown algae and in particular sargassum are an important source of antioxidants, vitamins, anti-inflammatories and, in particular, a sulfated polysaccharide known by the name of fucoidan. Due to its chemical composition, fucoidan has various beneficial bioactivities for human health, such as anticancer, immune system modulator, anti-inflammatory, prebiotic and anticoagulant. In addition, fucoidan has potential for the encapsulation and release of drugs and bioactivities and in bioremediation of water bodies. Due to these applications, in Mexico, there has been a recent interest in the development of a fucoidan extraction process. This paper reviews the biology of fucoidan, its bioactivities, the methods used for its extraction, and basic engineering for the extraction of fucoidan at the laboratory level from the algae Sargassum sinicola present in Mexican seas.

Downloads

Download data is not yet available.

References

Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011). Important determinants for fucoidan bioactivity: A critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds. Marine Drugs, 9(10), 2106–2130. DOI: https://doi.org/10.3390/md9102106

Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., & Dickinson, J. L. (2015). Fucoidan and cancer: A multifunctional molecule with anti-tumor potential. Marine Drugs, 13(4), 2327–2346. DOI: https://doi.org/10.3390/md13042327

Benbow, N. L., Webber, J. L., Karpiniec, S., Krasowska, M., Ferri, J. K., & Beattie, D. A. (2017). The influence of polyanion molecular weight on polyelectrolyte multilayers at surfaces: Protein adsorption and protein-polysaccharide complexation/stripping on natural polysaccharide films on solid supports. Physical Chemistry Chemical Physics, 19(35), 23790–23801. DOI: https://doi.org/10.1039/C7CP02599H

Brown, E. M., Allsopp, P. J., Magee, P. J., Gill, C. I., Nitecki, S., Strain, C. R., & Mcsorley, E. M. (2014). Seaweed and human health. Nutrition Reviews, 72(3), 205–216. DOI: https://doi.org/10.1111/nure.12091

Bui, L. M., Ngo, B. Q., Nguyen, N. D., Pham, T. D., & Tran, V. T. T. (2007). Studies on Fucoidan and its Production from Vietnamese Brown Seaweeds. ASEAN Journal on Science and Technology for Development, 22(4), 371–380. DOI: https://doi.org/10.3125/asean.v22i4.395

Chandía, N. P., & Matsuhiro, B. (2008). Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties. International Journal of Biological Macromolecules, 42(3), 235–240. DOI: https://doi.org/10.1016/j.ijbiomac.2007.10.023

Chávez, V., Uribe-Martínez, A., Cuevas, E., Rodríguez-Martínez, R. E., van Tussenbroek, B. I., Francisco, V., Estévez, M., Celis, L. B., Monroy-Velázquez, L. V., Leal-Bautista, R., Álvarez-Filip, L., García-Sánchez, M., Masia, L., & Silva, R. (2020). Massive influx of pelagic sargassum spp. On the coasts of the Mexican Caribbean 2014–2020: Challenges and opportunities. Water (Switzerland), 12(10), 1–24. DOI: https://doi.org/10.3390/w12102908

Citkowska, A., Szekalska, M., & Winnicka, K. (2019). Possibilities of fucoidan utilization in the development of pharmaceutical dosage forms. Marine Drugs, 17(8). DOI: https://doi.org/10.3390/md17080458

Desrochers, A., Cox, S., Oxenford, H., & Van Tussenbroek, B. (2020). Sargassum Uses Guide: A resource for Caribbean researchers, entrepreneurs and policy makers Lead. Food and Agriculture Organization of the United Nations (FAO) Produced, 97, 100.

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology and Hepatology, 14(8), 491–502. DOI: https://doi.org/10.1038/nrgastro.2017.75

Gotteland, M., Riveros, K., Gasaly, N., Carcamo, C., Magne, F., Liabeuf, G., Beattie, A., & Rosenfeld, S. (2020). The Pros and Cons of Using Algal Polysaccharides as Prebiotics. Frontiers in Nutrition, 7(September), 1–15. DOI: https://doi.org/10.3389/fnut.2020.00163

Hsu, H., & Hwang, P. (2019). Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy. Clinical and Translational Medicine, 8(1), 1–18. DOI: https://doi.org/10.1186/s40169-019-0234-9

Hsu, W. J., Lin, M. H., Kuo, T. C., Chou, C. M., Mi, F. L., Cheng, C. H., & Lin, C. W. (2020). Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells. International Journal of Biological Macromolecules, 149, 600–608 DOI: https://doi.org/10.1016/j.ijbiomac.2020.01.256

Huang, Y. C., & Lam, U. I. (2011). Chitosan/fucoidan pH sensitive nanoparticles for oral delivery system. Journal of the Chinese Chemical Society, 58(6), 779–785. DOI: https://doi.org/10.1002/jccs.201190121

Ikeguchi, M., Yamamoto, M., Arai, Y., Maeta, Y., Ashida, K., Katano, K., Miki, Y., & Kimura, T. (2011). Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer. Oncology Letters, 2(2), 319–322. https://doi.org/10.3892/ol.2011.254 DOI: https://doi.org/10.3892/ol.2011.254

Jun, J. Y., Jung, M. J., Jeong, I. H., Yamazaki, K., Kawai, Y., & Kim, B. M. (2018). Antimicrobial and antibiofilm activities of sulfated polysaccharides from marine algae against dental plaque bacteria. Marine Drugs, 16(9). DOI: https://doi.org/10.3390/md16090301

Langkawi, P., Kaedah, K., Fukoidan, P., Hasil, T., & Fukosa, K. (2018). EFFECT OF EXTRACTION METHODS ON THE YIELD, FUCOSE CONTENT AND PURITY OF FUCOIDAN FROM Sargassum sp. OBTAINED FROM PULAU LANGKAWI, MALAYSIA. Malaysian Journal of Analytical Science, 22(1), 87–94. DOI: https://doi.org/10.17576/mjas-2018-2201-11

Li, B., Lu, F., Wei, X., & Zhao, R. (2008). Fucoidan: Structure and bioactivity. Molecules, 13(8), 1671–1695. DOI: https://doi.org/10.3390/molecules13081671

Lin, Y., Qi, X., Liu, H., Xue, K., Xu, S., & Tian, Z. (2020). The anti-cancer effects of fucoidan: A review of both in vivo and in vitro investigations. Cancer Cell International, 20(1), 1–14. DOI: https://doi.org/10.1186/s12935-020-01233-8

Luthuli, S., Wu, S., Cheng, Y., Zheng, X., Wu, M., & Tong, H. (2019). Therapeutic effects of fucoidan: A review on recent studies. Marine Drugs, 17(9). DOI: https://doi.org/10.3390/md17090487

Moll, S., & Roberts, H. R. (2002). Overview of anticoagulant drugs for the future. Seminars in Hematology, 39(3), 145–157. https://doi.org/10.1053/shem.2002.34087Motta, L., & Sofía, R. (2013). Evaluación del potencial del uso de las algas de arribazón conocidas como sargazo. Journal of Chemical Information and Modeling, 53(9), 1689–1699. DOI: https://doi.org/10.1053/shem.2002.34087

Oka, S., Okabe, M., Tsubura, S., Mikami, M., & Imai, A. (2020). Properties of fucoidans beneficial to oral healthcare. Odontology, 108(1), 34–42. DOI: https://doi.org/10.1007/s10266-019-00437-3

Pacheco-Ruíz, I., Zertuche-González, J. A., Chee-Barragán, A., & Blanco-Betancourt, R. (1998). Distribution and quantification of Sargassum beds along the West Coast of the Gulf of California, Mexico. Botanica Marina, 41(2), 203–208. DOI: https://doi.org/10.1515/botm.1998.41.1-6.203

Ponce, N. M. A., & Stortz, C. A. (2020). A Comprehensive and Comparative Analysis of the Fucoidan Compositional Data Across the Phaeophyceae. Frontiers in Plant Science, 11(November). DOI: https://doi.org/10.3389/fpls.2020.556312

Saeed, M., Arain, M. A., Ali Fazlani, S., Marghazani, I. B., Umar, M., Soomro, J., Bhutto, Z. A., Soomro, F., Noreldin, A. E., Abd El-Hack, M. E., Elnesr, S. S., Farag, M. R., Dhama, K., Chao, S., & Alagawany, M. (2021). A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms. Aquaculture Nutrition, 27(3), 633–654 DOI: https://doi.org/10.1111/anu.13233

Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S. K. (2013). Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer. International Journal of Biological Macromolecules, 60, 366–374. DOI: https://doi.org/10.1016/j.ijbiomac.2013.06.030

Skriptsova, A. V. (2016). Seasonal variations in the fucoidan content of brown algae from Peter the Great Bay, Sea of Japan. Russian Journal of Marine Biology, 42(4), 351–356. DOI: https://doi.org/10.1134/S1063074016040106

Ustyuzhanina, N. E., Ushakova, N. A., Zyuzina, K. A., Bilan, M. I., Elizarova, A. L., Somonova, O. V., Madzhuga, A. V., Krylov, V. B., Preobrazhenskaya, M. E., Usov, A. I., Kiselevskiy, M. V., & Nifantiev, N. E. (2013). Influence of fucoidans on hemostatic system. Marine Drugs, 11(7), 2444–2458. DOI: https://doi.org/10.3390/md11072444

Wang, S. H., Huang, C. Y., Chen, C. Y., Chang, C. C., Huang, C. Y., Dong, C. Di, & Chang, J. S. (2020). Structure and Biological Activity Analysis of Fucoidan Isolated from Sargassum siliquosum. ACS Omega, 5(50), 32447–32455. DOI: https://doi.org/10.1021/acsomega.0c04591

Yen, H. W., Yang, S. C., Chen, C. H., Jesisca, & Chang, J. S. (2015). Supercritical fluid extraction of valuable compounds from microalgal biomass. Bioresource Technology, 184, 291–296. DOI: https://doi.org/10.1016/j.biortech.2014.10.030

Zayed, A., & Ulber, R. (2020). Fucoidans: Downstream processes and recent applications. Marine Drugs, 18(3), 1–22. DOI: https://doi.org/10.3390/md18030170

Published

2023-07-17

How to Cite

López Cuéllar, A. R. ., & Ramos Clamont Montfort, G. . (2023). Revisión sobre las características biológicas y estructurales de fucoidan y la posibilidad de extraerlo a partir de Sargassum sinicola. Revista Investigación y Desarrollo en Ciencia y Tecnología de Alimentos, 8(1), 298–308. https://doi.org/10.29105/idcyta.v8i1.41